Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR-induced lipogenesis

Background and purpose: Activation of liver X receptor (LXR) by its ligand T0901317 (T317) enhances interferon-γ (IFNγ) production to inhibit tumor growth. However, induction of severe hypertriglyceridemia and fatty liver by T317 limits its application. The naphthylacetic acid modified D-enantiomeri...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Feng, Ke, Ma, Chuanrui, Liu, Yuxin, Yang, Xiaoxiao, Yang, Zhimou, Chen, Yaoxia, Xu, Tengyan, Yang, Chengbiao, Zhang, Shuang, Li, Qi, Wei, Zhuo, Zhao, Dan, Zeng, Peng, Han, Jihong, Gao, Jie, Chen, Yuanli, Duan, Yajun
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806465/
https://ncbi.nlm.nih.gov/pubmed/33456564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.53139
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