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Substrate-specific recognition of IKKs mediated by USP16 facilitates autoimmune inflammation
The classic NF-κB pathway plays crucial roles in various immune responses and inflammatory diseases. Its key kinase, IKKβ, participates in a variety of pathological and physiological processes by selectively recognizing its downstream substrates, including p105, p65, and IκBα, but the specific mecha...
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| Veröffentlicht in: | Sci Adv |
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| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Association for the Advancement of Science
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7806237/ https://ncbi.nlm.nih.gov/pubmed/33523871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc4009 |
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