Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3

Histone 3 Lys27 (H3K27) trimethyltransferase Ezh2 is implicated in the pathogenesis of autoimmune inflammation. Nevertheless, the role of Ezh2 in macrophage/microglial activation remains to be defined. In this study, we identified that macrophage/microglial H3K27me3 or Ezh2, rather than functioning...

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Vydáno v:J Exp Med
Hlavní autoři: Zhang, Xingli, Wang, Yan, Yuan, Jia, Li, Ni, Pei, Siyu, Xu, Jing, Luo, Xuan, Mao, Chaoming, Liu, Junli, Yu, Tao, Gan, Shucheng, Zheng, Qianqian, Liang, Yinming, Guo, Weixiang, Qiu, Ju, Constantin, Gabriela, Jin, Jin, Qin, Jun, Xiao, Yichuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940261/
https://ncbi.nlm.nih.gov/pubmed/29626115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171417
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