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Peli1 impairs microglial Aβ phagocytosis through promoting C/EBPβ degradation
Amyloid-β (Aβ) accumulation in the brain is a hallmark of Alzheimer’s disease (AD) pathology. However, the molecular mechanism controlling microglial Aβ phagocytosis is poorly understood. Here we found that the E3 ubiquitin ligase Pellino 1 (Peli1) is induced in the microglia of AD-like five familia...
שמור ב:
| הוצא לאור ב: | PLoS Biol |
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| Main Authors: | , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Public Library of Science
2020
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7561136/ https://ncbi.nlm.nih.gov/pubmed/33017390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000837 |
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