Peli1 impairs microglial Aβ phagocytosis through promoting C/EBPβ degradation

Amyloid-β (Aβ) accumulation in the brain is a hallmark of Alzheimer’s disease (AD) pathology. However, the molecular mechanism controlling microglial Aβ phagocytosis is poorly understood. Here we found that the E3 ubiquitin ligase Pellino 1 (Peli1) is induced in the microglia of AD-like five familia...

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Dades bibliogràfiques
Publicat a:PLoS Biol
Autors principals: Xu, Jing, Yu, Tao, Pietronigro, Enrica Caterina, Yuan, Jia, Arioli, Jessica, Pei, Yifei, Luo, Xuan, Ye, Jialin, Constantin, Gabriela, Mao, Chaoming, Xiao, Yichuan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Short Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7561136/
https://ncbi.nlm.nih.gov/pubmed/33017390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000837
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