Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24

Stat6 is known to drive macrophage M2 polarization. However, how macrophage polarization is fine-tuned by Stat6 is poorly understood. Here, we find that Lys383 of Stat6 is acetylated by the acetyltransferase CREB-binding protein (CBP) during macrophage activation to suppress macrophage M2 polarizati...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Yu, Tao, Gan, Shucheng, Zhu, Qingchen, Dai, Dongfang, Li, Ni, Wang, Hui, Chen, Xiaosong, Hou, Dan, Wang, Yan, Pan, Qiang, Xu, Jing, Zhang, Xingli, Liu, Junli, Pei, Siyu, Peng, Chao, Wu, Ping, Romano, Simona, Mao, Chaoming, Huang, Mingzhu, Zhu, Xiaodong, Shen, Kunwei, Qin, Jun, Xiao, Yichuan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761150/
https://ncbi.nlm.nih.gov/pubmed/31554795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12384-2
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