Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X

USP9X is a conserved deubiquitinase (DUB) that regulates multiple cellular processes. Dysregulation of USP9X has been linked to cancers and X-linked intellectual disability. Here, we report the crystal structure of the USP9X catalytic domain at 2.5-Å resolution. The structure reveals a canonical USP...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Paudel, Prajwal, Zhang, Qi, Leung, Charles, Greenberg, Harrison C., Guo, Yusong, Chern, Yi-Hsuan, Dong, Aiping, Li, Yanjun, Vedadi, Masoud, Zhuang, Zhihao, Tong, Yufeng
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462090/
https://ncbi.nlm.nih.gov/pubmed/30914461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815027116
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