Modeling the Binding Mechanism of Remdesivir, Favilavir, and Ribavirin to SARS-CoV-2 RNA-Dependent RNA Polymerase

[Image: see text] Recent efforts to repurpose drugs to combat COVID-19 have identified Remdesivir as a candidate. It acts on the RNA-dependent, RNA polymerase (RdRp) of the SARS-CoV-2 virus, a protein complex responsible for mediating replication of the virus’s genome. However, its exact action mech...

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Argitaratua izan da:ACS Cent Sci
Egile Nagusiak: Byléhn, Fabian, Menéndez, Cintia A., Perez-Lemus, Gustavo R., Alvarado, Walter, de Pablo, Juan J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2021
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7805600/
https://ncbi.nlm.nih.gov/pubmed/33527086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c01242
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