Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

The pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global crisis. Replication of SARS-CoV-2 requires the viral RNA-dependent RNA polymerase (RdRp) enzyme, a target of the antiviral drug remdesivir. Here we report...

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Vydáno v:Science
Hlavní autoři: Yin, Wanchao, Mao, Chunyou, Luan, Xiaodong, Shen, Dan-Dan, Shen, Qingya, Su, Haixia, Wang, Xiaoxi, Zhou, Fulai, Zhao, Wenfeng, Gao, Minqi, Chang, Shenghai, Xie, Yuan-Chao, Tian, Guanghui, Jiang, He-Wei, Tao, Sheng-Ce, Shen, Jingshan, Jiang, Yi, Jiang, Hualiang, Xu, Yechun, Zhang, Shuyang, Zhang, Yan, Xu, H. Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199908/
https://ncbi.nlm.nih.gov/pubmed/32358203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abc1560
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