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Mechanism of SARS-CoV-2 polymerase stalling by remdesivir
Remdesivir is the only FDA-approved drug for the treatment of COVID-19 patients. The active form of remdesivir acts as a nucleoside analog and inhibits the RNA-dependent RNA polymerase (RdRp) of coronaviruses including SARS-CoV-2. Remdesivir is incorporated by the RdRp into the growing RNA product a...
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| Published in: | Nat Commun |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group UK
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7804290/ https://ncbi.nlm.nih.gov/pubmed/33436624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20542-0 |
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