Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

Remdesivir is the only FDA-approved drug for the treatment of COVID-19 patients. The active form of remdesivir acts as a nucleoside analog and inhibits the RNA-dependent RNA polymerase (RdRp) of coronaviruses including SARS-CoV-2. Remdesivir is incorporated by the RdRp into the growing RNA product a...

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Udgivet i:Nat Commun
Main Authors: Kokic, Goran, Hillen, Hauke S., Tegunov, Dimitry, Dienemann, Christian, Seitz, Florian, Schmitzova, Jana, Farnung, Lucas, Siewert, Aaron, Höbartner, Claudia, Cramer, Patrick
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804290/
https://ncbi.nlm.nih.gov/pubmed/33436624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20542-0
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