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Structural basis of TFIIH activation for nucleotide excision repair

Nucleotide excision repair (NER) is the major DNA repair pathway that removes UV-induced and bulky DNA lesions. There is currently no structure of NER intermediates, which form around the large multisubunit transcription factor IIH (TFIIH). Here we report the cryo-EM structure of an NER intermediate...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Kokic, Goran, Chernev, Aleksandar, Tegunov, Dimitry, Dienemann, Christian, Urlaub, Henning, Cramer, Patrick
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599211/
https://ncbi.nlm.nih.gov/pubmed/31253769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10745-5
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