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Structures of transcription pre-initiation complex with TFIIH and Mediator
For transcription initiation, RNA polymerase (Pol) II assembles with general transcription factors on promoter DNA to form the pre-initiation complex (PIC). We report cryo-EM structures of the yeast PIC and PIC-core Mediator (cMed) complex at nominal resolutions of 4.7 Å and 5.8 Å, respectively. The...
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| Publicado no: | Nature |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6078178/ https://ncbi.nlm.nih.gov/pubmed/29088706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24282 |
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