CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized mice

Chronic hepatitis B virus (HBV) infection is a major public health problem. New treatment approaches are needed because current treatments do not target covalently closed circular DNA (cccDNA), the template for HBV replication, and rarely clear the virus. We harnessed adeno-associated virus (AAV) ve...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Stone, Daniel, Long, Kelly R., Loprieno, Michelle A., De Silva Feelixge, Harshana S., Kenkel, Elizabeth J., Liley, R. Matt, Rapp, Stephen, Roychoudhury, Pavitra, Nguyen, Thuy, Stensland, Laurence, Colón-Thillet, Rossana, Klouser, Lindsay M., Weber, Nicholas D., Le, Connie, Wagoner, Jessica, Goecker, Erin A., Li, Alvason Zhenhua, Eichholz, Karsten, Corey, Lawrence, Tyrrell, D. Lorne, Greninger, Alexander L., Huang, Meei-Li, Polyak, Stephen J., Aubert, Martine, Sagartz, John E., Jerome, Keith R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7803634/
https://ncbi.nlm.nih.gov/pubmed/33473359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.11.014
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