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Intrabacterial Metabolism Obscures the Successful Prediction of an InhA Inhibitor of Mycobacterium tuberculosis

Tuberculosis, caused by Mycobacterium tuberculosis (M. tuberculosis), kills 1.6 million people annually. To bridge the gap between structure- and cell-based drug discovery strategies, we are pioneering a computer-aided discovery paradigm that merges structure-based virtual screening with ligand-base...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Infect Dis
Prif Awduron: Wang, Xin, Perryman, Alexander L., Li, Shao-Gang, Paget, Steve D., Stratton, Thomas P., Lemenze, Alex, Olson, Arthur J., Ekins, Sean, Kumar, Pradeep, Freundlich, Joel S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801736/
https://ncbi.nlm.nih.gov/pubmed/31625383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.9b00295
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