Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity

The pathogenesis of ulcerative colitis (UC), a major type of inflammatory bowel disease, remains unknown. No model exists that adequately recapitulates the complexity of clinical UC. Here, we take advantage of induced pluripotent stem cells (iPSCs) to develop an induced human UC-derived organoid (iH...

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Publicado en:Nat Commun
Autores principales: Sarvestani, Samaneh K., Signs, Steven, Hu, Bo, Yeu, Yunku, Feng, Hao, Ni, Ying, Hill, David R., Fisher, Robert C., Ferrandon, Sylvain, DeHaan, Reece K., Stiene, Jennifer, Cruise, Michael, Hwang, Tae Hyun, Shen, Xiling, Spence, Jason R., Huang, Emina H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801686/
https://ncbi.nlm.nih.gov/pubmed/33431859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20351-5
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