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Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity

The pathogenesis of ulcerative colitis (UC), a major type of inflammatory bowel disease, remains unknown. No model exists that adequately recapitulates the complexity of clinical UC. Here, we take advantage of induced pluripotent stem cells (iPSCs) to develop an induced human UC-derived organoid (iH...

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Τόπος έκδοσης:	Nat Commun
Κύριοι συγγραφείς:	Sarvestani, Samaneh K., Signs, Steven, Hu, Bo, Yeu, Yunku, Feng, Hao, Ni, Ying, Hill, David R., Fisher, Robert C., Ferrandon, Sylvain, DeHaan, Reece K., Stiene, Jennifer, Cruise, Michael, Hwang, Tae Hyun, Shen, Xiling, Spence, Jason R., Huang, Emina H.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Nature Publishing Group UK 2021
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7801686/ https://ncbi.nlm.nih.gov/pubmed/33431859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20351-5
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Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity

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