Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity

The pathogenesis of ulcerative colitis (UC), a major type of inflammatory bowel disease, remains unknown. No model exists that adequately recapitulates the complexity of clinical UC. Here, we take advantage of induced pluripotent stem cells (iPSCs) to develop an induced human UC-derived organoid (iH...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Sarvestani, Samaneh K., Signs, Steven, Hu, Bo, Yeu, Yunku, Feng, Hao, Ni, Ying, Hill, David R., Fisher, Robert C., Ferrandon, Sylvain, DeHaan, Reece K., Stiene, Jennifer, Cruise, Michael, Hwang, Tae Hyun, Shen, Xiling, Spence, Jason R., Huang, Emina H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801686/
https://ncbi.nlm.nih.gov/pubmed/33431859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20351-5
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