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HERC2 inactivation abrogates nucleolar localization of RecQ helicases BLM and WRN
The nucleolus is a nuclear structure composed of ribosomal DNA (rDNA), and functions as a site for rRNA synthesis and processing. The rDNA is guanine-rich and prone to form G-quadruplex (G4), a secondary structure of DNA. We have recently found that HERC2, an HECT ubiquitin ligase, promotes BLM and...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7801386/ https://ncbi.nlm.nih.gov/pubmed/33432007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79715-y |
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