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Structural mechanisms of human RecQ helicases WRN and BLM

The RecQ family DNA helicases Werner syndrome protein (WRN) and Bloom syndrome protein (BLM) play a key role in protecting the genome against deleterious changes. In humans, mutations in these proteins lead to rare genetic diseases associated with cancer predisposition and accelerated aging. WRN and...

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Detalhes bibliográficos
Autor principal: Kitano, Ken
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4212688/
https://ncbi.nlm.nih.gov/pubmed/25400656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2014.00366
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