Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. Although rigorous efforts identified the presence of ‘cancer stem cells (CSCs)’ in PDAC and molecular markers for them, stem cell dynamics in vivo have not been clearly demonstrated. Here we focused on Doublecortin-like kinase 1 (Dclk...

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Pubblicato in:eLife
Autori principali: Maruno, Takahisa, Fukuda, Akihisa, Goto, Norihiro, Tsuda, Motoyuki, Ikuta, Kozo, Hiramatsu, Yukiko, Ogawa, Satoshi, Nakanishi, Yuki, Yamaga, Yuichi, Yoshioka, Takuto, Takaori, Kyoichi, Uemoto, Shinji, Saur, Dieter, Chiba, Tsutomu, Seno, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2021
Soggetti:
Cancer Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7800378/
https://ncbi.nlm.nih.gov/pubmed/33393460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55117
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