Epithelial EP4 plays an essential role in maintaining homeostasis in colon

Colonic epithelial cells comprise the mucosal barrier, and their dysfunction promotes microbial invasion from the gut lumen and induces the development of intestinal inflammation. The EP4 receptor is known to mediate the protective effect of prostaglandin (PG) E(2) in the gastrointestinal tract; how...

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Pubblicato in:Sci Rep
Autori principali: Matsumoto, Yoshihide, Nakanishi, Yuki, Yoshioka, Takuto, Yamaga, Yuichi, Masuda, Tomonori, Fukunaga, Yuichi, Sono, Makoto, Yoshikawa, Takaaki, Nagao, Munemasa, Araki, Osamu, Ogawa, Satoshi, Goto, Norihiro, Hiramatsu, Yukiko, Breyer, Richard M., Fukuda, Akihisa, Seno, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811535/
https://ncbi.nlm.nih.gov/pubmed/31645712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51639-2
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