Lineage tracing and targeting of IL17RB(+) tuft cell-like human colorectal cancer stem cells

Cancer stem cell (CSC)-specific markers may be potential therapeutic targets. We previously identified that Dclk1, a tuft cell marker, marks tumor stem cells (TSCs) in mouse intestinal adenomas. Based on the analysis of mouse Dclk1(+) tumor cells, we aimed to identify a CSC-specific cell surface mar...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Goto, Norihiro, Fukuda, Akihisa, Yamaga, Yuichi, Yoshikawa, Takaaki, Maruno, Takahisa, Maekawa, Hisatsugu, Inamoto, Susumu, Kawada, Kenji, Sakai, Yoshiharu, Miyoshi, Hiroyuki, Taketo, Makoto Mark, Chiba, Tsutomu, Seno, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601016/
https://ncbi.nlm.nih.gov/pubmed/31182574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1900251116
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