The BRG1/SOX9 axis is critical for acinar cell–derived pancreatic tumorigenesis

Chromatin remodeler Brahma related gene 1 (BRG1) is silenced in approximately 10% of human pancreatic ductal adenocarcinomas (PDAs). We previously showed that BRG1 inhibits the formation of intraductal pancreatic mucinous neoplasm (IPMN) and that IPMN-derived PDA originated from ductal cells. Howeve...

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Vydáno v:J Clin Invest
Hlavní autoři: Tsuda, Motoyuki, Fukuda, Akihisa, Roy, Nilotpal, Hiramatsu, Yukiko, Leonhardt, Laura, Kakiuchi, Nobuyuki, Hoyer, Kaja, Ogawa, Satoshi, Goto, Norihiro, Ikuta, Kozo, Kimura, Yoshito, Matsumoto, Yoshihide, Takada, Yutaka, Yoshioka, Takuto, Maruno, Takahisa, Yamaga, Yuichi, Kim, Grace E., Akiyama, Haruhiko, Ogawa, Seishi, Wright, Christopher V., Saur, Dieter, Takaori, Kyoichi, Uemoto, Shinji, Hebrok, Matthias, Chiba, Tsutomu, Seno, Hiroshi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063489/
https://ncbi.nlm.nih.gov/pubmed/30010625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94287
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