CTLA-4 blockade and interferon-α induce proinflammatory transcriptional changes in the tumor immune landscape that correlate with pathologic response in melanoma

Patients with locally/regionally advanced melanoma were treated with neoadjuvant combination immunotherapy with high-dose interferon α-2b (HDI) and ipilimumab in a phase I clinical trial. Tumor specimens were obtained prior to the initiation of neoadjuvant therapy, at the time of surgery and progres...

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Publicado en:PLoS One
Autores principales: Khunger, Arjun, Piazza, Erin, Warren, Sarah, Smith, Thomas H., Ren, Xing, White, Andrew, Elliott, Nathan, Cesano, Alessandra, Beechem, Joseph M., Kirkwood, John M., Tarhini, Ahmad A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7799833/
https://ncbi.nlm.nih.gov/pubmed/33428680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0245287
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