The impact of CTLA-4 blockade and interferon-α on clonality of T-cell repertoire in the tumor microenvironment and peripheral blood of metastatic melanoma patients

Patients with metastatic melanoma were treated with tremelimumab and interferon-α (IFN) in a previously reported clinical trial [NCT00610857]. Responses were assessed by RECIST criteria as complete (CR) or partial (PR), stable disease (SD) or progressive disease (PD). In this study, T-cell receptor...

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Bibliographische Detailangaben
Veröffentlicht in:Oncoimmunology
Hauptverfasser: Khunger, Arjun, Rytlewski, Julie A., Fields, Paul, Yusko, Erik C., Tarhini, Ahmad A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2019
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791420/
https://ncbi.nlm.nih.gov/pubmed/31646098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1652538
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