Association of Tumor Microenvironment T-Cell Repertoire and Mutational Load With Clinical Outcome After Sequential Checkpoint Blockade in Melanoma

To understand prognostic factors for outcome between differentially sequenced nivolumab and ipilimumab in a randomized phase II trial, we measured T-cell infiltration and PD-L1 by immunohistochemistry, T-cell repertoire metrics, and mutational load within the tumor. We used next-generation sequencin...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Yusko, Erik, Vignali, Marissa, Wilson, Richard K., Mardis, Elaine R., Hodi, F. Stephen, Horak, Christine, Chang, Han, Woods, David M., Robins, Harlan, Weber, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397694/
https://ncbi.nlm.nih.gov/pubmed/30635271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0226
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