Dual Angiotensin Receptor-Neprilysin Inhibition With Sacubitril/Valsartan Attenuates Systolic Dysfunction in Experimental Doxorubicin-Induced Cardiotoxicity

BACKGROUND: Doxorubicin (DOX) induces cardiotoxicity in part by activation of matrix metalloproteinases (MMPs). Sacubitril/valsartan (Sac/Val) exerts additive cardioprotective actions over renin-angiotensin-aldosterone inhibitors in preclinical models of myocardial infarction and in heart failure pa...

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Bibliografische gegevens
Gepubliceerd in:JACC CardioOncol
Hoofdauteurs: Boutagy, Nabil E., Feher, Attila, Pfau, Daniel, Liu, Zhao, Guerrera, Nicole M., Freeburg, Lisa A., Womack, Sydney J., Hoenes, Abigail C., Zeiss, Caroline, Young, Lawrence H., Spinale, Francis G., Sinusas, Albert J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2020
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7799406/
https://ncbi.nlm.nih.gov/pubmed/33437965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaccao.2020.09.007
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