Dual Angiotensin Receptor-Neprilysin Inhibition With Sacubitril/Valsartan Attenuates Systolic Dysfunction in Experimental Doxorubicin-Induced Cardiotoxicity

BACKGROUND: Doxorubicin (DOX) induces cardiotoxicity in part by activation of matrix metalloproteinases (MMPs). Sacubitril/valsartan (Sac/Val) exerts additive cardioprotective actions over renin-angiotensin-aldosterone inhibitors in preclinical models of myocardial infarction and in heart failure pa...

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Bibliographic Details
Published in:JACC CardioOncol
Main Authors: Boutagy, Nabil E., Feher, Attila, Pfau, Daniel, Liu, Zhao, Guerrera, Nicole M., Freeburg, Lisa A., Womack, Sydney J., Hoenes, Abigail C., Zeiss, Caroline, Young, Lawrence H., Spinale, Francis G., Sinusas, Albert J.
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7799406/
https://ncbi.nlm.nih.gov/pubmed/33437965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaccao.2020.09.007
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