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Treatment of Pulmonary Hypertension with Angiotensin II Receptor Blocker and Neprilysin Inhibitor Sacubitril/Valsartan

BACKGROUND: Angiotensin II has been implicated in maladaptive RV hypertrophy and fibrosis associated with pulmonary hypertension (PH). Natriuretic peptides decrease RV afterload by promoting pulmonary vasodilation and inhibiting vascular remodeling, but are degraded by neprilysin. We hypothesized th...

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Publicado en:Circ Heart Fail
Main Authors: Clements, Richard T., Vang, Alexander, Fernandez-Nicolas, Ana, Kue, Nouaying R., Mancini, Thomas J., Morrison, Alan R., Mallem, Krishna, McCullough, Danielle J., Choudhary, Gaurav
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857845/
https://ncbi.nlm.nih.gov/pubmed/31707802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.119.005819
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