Dual Angiotensin Receptor-Neprilysin Inhibition With Sacubitril/Valsartan Attenuates Systolic Dysfunction in Experimental Doxorubicin-Induced Cardiotoxicity

BACKGROUND: Doxorubicin (DOX) induces cardiotoxicity in part by activation of matrix metalloproteinases (MMPs). Sacubitril/valsartan (Sac/Val) exerts additive cardioprotective actions over renin-angiotensin-aldosterone inhibitors in preclinical models of myocardial infarction and in heart failure pa...

詳細記述

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書誌詳細
出版年:JACC CardioOncol
主要な著者: Boutagy, Nabil E., Feher, Attila, Pfau, Daniel, Liu, Zhao, Guerrera, Nicole M., Freeburg, Lisa A., Womack, Sydney J., Hoenes, Abigail C., Zeiss, Caroline, Young, Lawrence H., Spinale, Francis G., Sinusas, Albert J.
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2020
主題:
Original Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7799406/
https://ncbi.nlm.nih.gov/pubmed/33437965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaccao.2020.09.007
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