Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a multi‐system disease characterized primarily by progressive muscle weakness. Cognitive dysfunction is commonly observed in patients; however, factors influencing risk for cognitive dysfunction remain elusive. Using sparse canonical correlation analysis (sCCA)...

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Pubblicato in:EMBO Mol Med
Autori principali: Placek, Katerina, Benatar, Michael, Wuu, Joanne, Rampersaud, Evadnie, Hennessy, Laura, Van Deerlin, Vivianna M, Grossman, Murray, Irwin, David J, Elman, Lauren, McCluskey, Leo, Quinn, Colin, Granit, Volkan, Statland, Jeffrey M, Burns, Ted M, Ravits, John, Swenson, Andrea, Katz, Jon, Pioro, Erik P, Jackson, Carlayne, Caress, James, So, Yuen, Maiser, Samuel, Walk, David, Lee, Edward B, Trojanowski, John Q, Cook, Philip, Gee, James, Sha, Jin, Naj, Adam C, Rademakers, Rosa, Chen, Wenan, Wu, Gang, Paul Taylor, J, McMillan, Corey T
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7799365/
https://ncbi.nlm.nih.gov/pubmed/33270986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.202012595
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