Validation of serum neurofilaments as prognostic and potential pharmacodynamic biomarkers for ALS

OBJECTIVE: To identify preferred neurofilament assays and clinically validate serum neurofilament light (NfL) and phosphorylated neurofilament heavy (pNfH) as prognostic and potential pharmacodynamic biomarkers relevant to amyotrophic lateral sclerosis (ALS) therapy development. METHODS: In this pro...

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Publicat a:Neurology
Autors principals: Benatar, Michael, Zhang, Lanyu, Wang, Lily, Granit, Volkan, Statland, Jeffrey, Barohn, Richard, Swenson, Andrea, Ravits, John, Jackson, Carlayne, Burns, Ted M., Trivedi, Jaya, Pioro, Erik P., Caress, James, Katz, Jonathan, McCauley, Jacob L., Rademakers, Rosa, Malaspina, Andrea, Ostrow, Lyle W., Wuu, Joanne
Format: Artigo
Idioma:Inglês
Publicat: Lippincott Williams & Wilkins 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7371380/
https://ncbi.nlm.nih.gov/pubmed/32385188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000009559
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