Validation of serum neurofilaments as prognostic and potential pharmacodynamic biomarkers for ALS

OBJECTIVE: To identify preferred neurofilament assays and clinically validate serum neurofilament light (NfL) and phosphorylated neurofilament heavy (pNfH) as prognostic and potential pharmacodynamic biomarkers relevant to amyotrophic lateral sclerosis (ALS) therapy development. METHODS: In this pro...

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Publicado en:Neurology
Autores principales: Benatar, Michael, Zhang, Lanyu, Wang, Lily, Granit, Volkan, Statland, Jeffrey, Barohn, Richard, Swenson, Andrea, Ravits, John, Jackson, Carlayne, Burns, Ted M., Trivedi, Jaya, Pioro, Erik P., Caress, James, Katz, Jonathan, McCauley, Jacob L., Rademakers, Rosa, Malaspina, Andrea, Ostrow, Lyle W., Wuu, Joanne
Formato: Artigo
Lenguaje:Inglês
Publicado: Lippincott Williams & Wilkins 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7371380/
https://ncbi.nlm.nih.gov/pubmed/32385188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000009559
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