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HLA class I binding of mutant EGFR peptides in NSCLC is associated with improved survival

RATIONALE: Cancer-associated mutations have the potential to generate neoantigens and elicit CD8 positive T cell dependent adaptive immune responses. There are currently no reports of CD8 positive T cells with specificity for neoepitopes generated by EGFR mutations, which are driver oncogenes in a s...

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Detalhes bibliográficos
Publicado no:J Thorac Oncol
Main Authors: Dimou, Anastasios, Grewe, Paul, Sidney, John, Sette, Alessandro, Norman, Paul J., Doebele, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797166/
https://ncbi.nlm.nih.gov/pubmed/32927123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2020.08.023
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