Structure-Acid Lability Relationship of N-alkylated α,α-dialkylglycine Obtained via a Ugi Multicomponent Reaction

Using the classical Ugi four-component reaction to fuse an amine, ketone, carboxylic acid, and isocyanide, here we prepared a short library of N-alkylated α,α-dialkylglycine derivatives. Due to the polyfunctionality of the dipeptidic scaffold, this highly steric hindered system shows an interesting...

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Bibliographic Details
Published in:Molecules
Main Authors: Ramos-Tomillero, Iván, Sánchez, Marisa K., Rodríguez, Hortensia, Albericio, Fernando
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794957/
https://ncbi.nlm.nih.gov/pubmed/33401754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26010197
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