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α-Ketoglutaric acid in Ugi reactions and Ugi/aza-Wittig tandem reactions

A small library of bis- and tetraamides was synthesized by the Ugi reaction with α-ketoglutaric acid, tert-butyl isocyanide, aromatic aldehydes, and aromatic amines. When o-azidoanilines were used, azidated peptidomimetics were obtained, the post-cyclization of which by the aza-Wittig reaction yield...

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Hlavní autoři: Vladyslav O. Honcharov, Yana I. Sakhno, Olena H. Shvets, Vyacheslav E. Saraev, Svitlana V. Shishkina, Tetyana V. Shcherbakova, Valentyn A. Chebanov
Médium: Artigo
Jazyk:Inglês
Vydáno: Beilstein-Institut 2025-10-01
Edice:Beilstein Journal of Organic Chemistry
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On-line přístup:https://doi.org/10.3762/bjoc.21.157
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