Tetrahydropyranyl: A Non‐aromatic, Mild‐Acid‐Labile Group for Hydroxyl Protection in Solid‐Phase Peptide Synthesis

The use of the tetrahydropyranyl (Thp) group for the protection of serine and threonine side‐chain hydroxyl groups in solid‐phase peptide synthesis has not been widely investigated. Ser/Thr side‐chain hydroxyl protection with this acid‐labile and non‐aromatic moiety is presented here. Although Thp r...

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Publicat a:ChemistryOpen
Autors principals: Sharma, Anamika, Ramos‐Tomillero, Iván, El‐Faham, Ayman, Rodríguez, Hortensia, de la Torre, Beatriz G., Albericio, Fernando
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5390794/
https://ncbi.nlm.nih.gov/pubmed/28413752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201600157
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