Scope and Limitations of γ-Valerolactone (GVL) as a Green Solvent to be Used with Base for Fmoc Removal in Solid Phase Peptide Synthesis

GVL is a green solvent used in Fmoc-based solid-phase peptide synthesis. It is susceptible to ring opening in the presence of bases such as piperidines, which are used to remove the Fmoc protecting group. Here we studied the formation of the corresponding acyl piperidides by time-dependent monitorin...

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Détails bibliographiques
Auteurs principaux: Ashish Kumar, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio
Format: Artigo
Langue:Inglês
Publié: MDPI AG 2019-11-01
Collection:Molecules
Sujets:
piperidine
4-methylpiperidine
acyl piperidide
nmr
ir
dft
Accès en ligne:https://www.mdpi.com/1420-3049/24/21/4004
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