An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer

We have reported that autophagy is crucial for clearance of amyloidogenic human IAPP (hIAPP) oligomer, suggesting that an autophagy enhancer could be a therapeutic modality against human diabetes with amyloid accumulation. Here, we show that a recently identified autophagy enhancer (MSL-7) reduces h...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Kim, Jinyoung, Park, Kihyoun, Kim, Min Jung, Lim, Hyejin, Kim, Kook Hwan, Kim, Sun-Woo, Lee, Eun-Seo, Kim, Hyongbum (Henry), Kim, Sung Joo, Hur, Kyu Yeon, Kim, Jae Hyeon, Ahn, Jin Hee, Yoon, Kun-Ho, Kim, Ji-Won, Lee, Myung-Shik
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794419/
https://ncbi.nlm.nih.gov/pubmed/33420039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20454-z
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