Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes

Islet amyloid accumulation is a hallmark of human type 2 diabetes (T2D). In contrast to human islet amyloid polypeptide (hIAPP), murine islet amyloid polypeptide (mIAPP) does not exhibit amyloidogenic propensity. Because autophagy is important in the clearance of amyloid-like proteins, we studied tr...

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Detalhes bibliográficos
Main Authors: Kim, Jinyoung, Cheon, Hwanju, Jeong, Yeon Taek, Quan, Wenying, Kim, Kook Hwan, Cho, Jae Min, Lim, Yu-Mi, Oh, Seung Hoon, Jin, Sang-Man, Kim, Jae Hyeon, Lee, Moon-Kyu, Kim, Sunshin, Komatsu, Masaaki, Kang, Sang-Wook, Lee, Myung-Shik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109549/
https://ncbi.nlm.nih.gov/pubmed/25036705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69625
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