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Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes
NLRP1 and CARD8 are related cytosolic sensors that upon activation form supramolecular signalling complexes known as canonical inflammasomes, resulting in caspase−1 activation, cytokine maturation and/or pyroptotic cell death. NLRP1 and CARD8 use their C-terminal (CT) fragments containing a caspase...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7794386/ https://ncbi.nlm.nih.gov/pubmed/33420033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20320-y |
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