Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes

NLRP1 and CARD8 are related cytosolic sensors that upon activation form supramolecular signalling complexes known as canonical inflammasomes, resulting in caspase−1 activation, cytokine maturation and/or pyroptotic cell death. NLRP1 and CARD8 use their C-terminal (CT) fragments containing a caspase...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Robert Hollingsworth, L., David, Liron, Li, Yang, Griswold, Andrew R., Ruan, Jianbin, Sharif, Humayun, Fontana, Pietro, Orth-He, Elizabeth L., Fu, Tian-Min, Bachovchin, Daniel A., Wu, Hao
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794386/
https://ncbi.nlm.nih.gov/pubmed/33420033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20320-y
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