Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8

Nod-like receptor (NLR) proteins activate pyroptotic cell death and IL-1 driven inflammation by assembling and activating the inflammasome complex. Closely related sensor proteins NLRP1 and CARD8 undergo unique auto-proteolysis-dependent activation and are implicated in auto-inflammatory diseases; h...

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Publicado en:Nat Commun
Main Authors: Gong, Qin, Robinson, Kim, Xu, Chenrui, Huynh, Phuong Thao, Chong, Kelvin Han Chung, Tan, Eddie Yong Jun, Zhang, Jiawen, Boo, Zhao Zhi, Teo, Daniel Eng Thiam, Lay, Kenneth, Zhang, Yaming, Lim, John Soon Yew, Goh, Wah Ing, Wright, Graham, Zhong, Franklin L., Reversade, Bruno, Wu, Bin
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794362/
https://ncbi.nlm.nih.gov/pubmed/33420028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20319-5
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