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Conformational and migrational dynamics of slipped-strand DNA three-way junctions containing trinucleotide repeats

Expansions of CAG/CTG trinucleotide repeats in DNA are the cause of at least 17 degenerative human disorders, including Huntington’s Disease. Repeat instability is thought to occur via the formation of intrastrand hairpins during replication, repair, recombination, and transcription though relativel...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hu, Tianyu, Morten, Michael J., Magennis, Steven W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794359/
https://ncbi.nlm.nih.gov/pubmed/33420051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20426-3
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