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Conformational and migrational dynamics of slipped-strand DNA three-way junctions containing trinucleotide repeats

Expansions of CAG/CTG trinucleotide repeats in DNA are the cause of at least 17 degenerative human disorders, including Huntington’s Disease. Repeat instability is thought to occur via the formation of intrastrand hairpins during replication, repair, recombination, and transcription though relativel...

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Pubblicato in:Nat Commun
Autori principali: Hu, Tianyu, Morten, Michael J., Magennis, Steven W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794359/
https://ncbi.nlm.nih.gov/pubmed/33420051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20426-3
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