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Strand-specific effect of Rad26 and TFIIS in rescuing transcriptional arrest by CAG trinucleotide repeat slip-outs

Transcription induced CAG repeat instability is associated with fatal neurological disorders. Genetic approaches found transcription-coupled nucleotide excision repair (TC-NER) factor CSB protein and TFIIS play critical roles in modulating the repeat stability. Here, we took advantage of an in vitro...

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Pubblicato in:Nucleic Acids Res
Autori principali: Xu, Jun, Chong, Jenny, Wang, Dong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287942/
https://ncbi.nlm.nih.gov/pubmed/34197619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab573
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