Visualising G-quadruplex DNA dynamics in live cells by fluorescence lifetime imaging microscopy

Guanine rich regions of oligonucleotides fold into quadruple-stranded structures called G-quadruplexes (G4s). Increasing evidence suggests that these G4 structures form in vivo and play a crucial role in cellular processes. However, their direct observation in live cells remains a challenge. Here we...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Summers, Peter A., Lewis, Benjamin W., Gonzalez-Garcia, Jorge, Porreca, Rosa M., Lim, Aaron H. M., Cadinu, Paolo, Martin-Pintado, Nerea, Mann, David J., Edel, Joshua B., Vannier, Jean Baptiste, Kuimova, Marina K., Vilar, Ramon
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794231/
https://ncbi.nlm.nih.gov/pubmed/33420085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20414-7
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