Binding of Small Molecules to G-quadruplex DNA in Cells Revealed by Fluorescence Lifetime Imaging Microscopy of o-BMVC Foci

G-quadruplex (G4) structures have recently received increasing attention as a potential target for cancer research. We used time-gated fluorescence lifetime imaging microscopy (FLIM) with a G4 fluorescent probe, 3,6-bis(1-methyl-2-vinylpyridinium) carbazole diiodide (o-BMVC), to measure the number o...

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Veröffentlicht in:Molecules
Hauptverfasser: Tseng, Ting-Yuan, Chu, I-Te, Lin, Shang-Jyun, Li, Jie, Chang, Ta-Chau
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337594/
https://ncbi.nlm.nih.gov/pubmed/30583464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24010035
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