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Leveraging TCR affinity in adoptive immunotherapy against shared tumor/self antigens

Adoptive cellular therapy (ACT) using T-cell receptor (TCR)-engineered lymphocytes holds promise for eradication of disseminated tumors, but also an inherent risk of pathologic autoimmunity if targeted antigens or antigenic mimics are expressed by normal tissues. We evaluated whether modulating TCR...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Miller, Aaron M., Bahmanof, Milad, Zehn, Dietmar, Cohen, Ezra E. W., Schoenberger, Stephen P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793606/
https://ncbi.nlm.nih.gov/pubmed/30482746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0371
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