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Leveraging TCR affinity in adoptive immunotherapy against shared tumor/self antigens

Adoptive cellular therapy (ACT) using T-cell receptor (TCR)-engineered lymphocytes holds promise for eradication of disseminated tumors, but also an inherent risk of pathologic autoimmunity if targeted antigens or antigenic mimics are expressed by normal tissues. We evaluated whether modulating TCR...

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Dades bibliogràfiques
Publicat a:Cancer Immunol Res
Autors principals: Miller, Aaron M., Bahmanof, Milad, Zehn, Dietmar, Cohen, Ezra E. W., Schoenberger, Stephen P.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793606/
https://ncbi.nlm.nih.gov/pubmed/30482746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0371
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