Carregant...
Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection
The failure to eliminate self-reactive T cells during negative selection is a prerequisite for autoimmunity. To escape deletion, autoreactive T-cell receptors (TCRs) may form unstable complexes with self-peptide–MHC by adopting suboptimal binding topologies compared with anti-microbial TCRs. Alterna...
Guardat en:
| Autors principals: | , , , , |
|---|---|
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2011
|
| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3061028/ https://ncbi.nlm.nih.gov/pubmed/21297580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.21 |
| Etiquetes: |
Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|