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Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection
The failure to eliminate self-reactive T cells during negative selection is a prerequisite for autoimmunity. To escape deletion, autoreactive T-cell receptors (TCRs) may form unstable complexes with self-peptide–MHC by adopting suboptimal binding topologies compared with anti-microbial TCRs. Alterna...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3061028/ https://ncbi.nlm.nih.gov/pubmed/21297580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.21 |
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