ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism

Inter-α-inhibitor heavy chain 4 (ITIH4) is a poorly characterized plasma protein that is proteolytically processed in multiple pathological conditions. However, no biological function of ITIH4 has been identified. Here, we show that ITIH4 is cleaved by several human proteases within a protease-susce...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Pihl, Rasmus, Jensen, Rasmus K., Poulsen, Emil C., Jensen, Lisbeth, Hansen, Annette G., Thøgersen, Ida B., Dobó, József, Gál, Péter, Andersen, Gregers R., Enghild, Jan J., Thiel, Steffen
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793589/
https://ncbi.nlm.nih.gov/pubmed/33523981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba7381
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